After a two-and-a-half year long renovation, the Museum re-opened in June 2004 with the addition of an education center, a new cafe and shop, more adequate handicap accessibility, and a heating and cooling system that will allow the Museum to remain open year-round. Besides launching its first-ever program of temporary exhibitions, the Museum has created a special gallery devoted to Noguchi's celebrated work in interior design.

Although the renovated Museum has a fresh look, great care has been taken to maintiain the original character of the building, which was integral to Noguchi's vision for the Museum. The raw industrial space of the former photo-engraving plant serves as a superb backdrop for the artist's sculpture.

The Noguchi Museum offers a variety of education and public programs that seek to introduce the work and vision of Isamu Noguchi to diverse audiences. These programs encourage the investigation of Noguchi's work from different vantage points, and support participants as they experience the artist's work from their own perspectives.

In addition to housing and exhibiting a collection of Noguchi's works, the Museum also serves the international art community by loaning works to other institutions for special exhibitions, organizing traveling exhibitions, and offering scholars access to the artist's extensive archives, including his records, correspondence, manuscripts, and photographs. The Museum also collaborates with The Isamu Noguchi Foundation in Japan.